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This Week in Virology
TWiV 1275: An amazing sequence and a gutsy therapy
By Vincent Racaniello on Nov 30, 2025 12:00 am
TWiV explains the Nobel Prize-winning discovery of pre-mRNA splicing, and engineering bacteriophage to deliver proteins to the human intestine.Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker
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Become a patron of TWiV!Links for this episode
- Support science education at MicrobeTV
- Immune 100 live at the Incubator
- Spliced segments of adenovirus mRNA (PNAS)
- An amazing sequence in adenovirus mRNA (Cell)
- Nobel Prize for mRNA splicing (Nobel)
- A predominant undecanucleotide in adenovirus late mRNAs (Cell)
- Splicing RNA with Phillip A. Sharp (ASM)
- Protein production in the gut by engineered phage (Nat Biotech)
- Engineered phage T4 (Curr Op Virol)
- Timestamps by JoleneRamsey. Thanks!
Weekly Picks
Brianne – Can You Identify These Lines from Classic SciFi Novels?Kathy – Saturday Morning Physics, Photograph 51 and JCE article Rich – Wikipedia:Wiki Science Competition 2025 in the United States Jolene – Data visualization workshop Vincent – Transformer: The Deep Chemistry of Life and Death by Nick Lane
Intro music is by Ronald Jenkees
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Content in this podcast should not be construed as medical advice.
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